YXG-158

• Catalog Number: orb2277886
• Category: Small Molecules
• Description: YXG-158 (Compound 23-h), an orally active androgen receptor (AR) degrader and cytochrome P450 17A1 (CYP17A1) inhibitor, exhibits AR degradation with a DC50 of 1.28 μM and CYP17A1 inhibition with an IC50 of 100 nM. It is under investigation for potential use in research on enzalutamide-resistant prostate cancer [1].
• CAS Number: 2952994-34-0
• Purity: 98.00%
• MW: 473.62
• SMILES: C[C@@]12[C@]([C@]3([C@@]([C@]4(C)C(=CC3)C[C@@H](NC(=O)C5=CC=C(F)C=C5)CC4)(CC1)[H])[H])(CC=C2N6C=C(C)N=C6)[H]
• Formula: C₃₀H₃₆FN₃O
• Biological Activity: YXG-158 (Compound 23-h), an orally active androgen receptor (AR) degrader and cytochrome P450 17A1 (CYP17A1) inhibitor, exhibits AR degradation with a DC50 of 1.28 μM and CYP17A1 inhibition with an IC50 of 100 nM. It is under investigation for potential use in research on enzalutamide-resistant prostate cancer [1].
• Storage: -20°C
• Note: For research use only
• Expiration Date: 12 months from date of receipt.