YQ128

• Catalog Number: orb1089633
• Category: Small Molecules
• Description: YQ128 is a potent and selective second-generation NLRP3 (NOD-like receptor P3) inflammasome inhibitor with an IC50 of 0.30 ± 0.01 μM. Further studies from in vitro and in vivo models confirmed its selective inhibition on the NLRP3 inflammasome and its brain penetration. Furthermore, pharmacokinetic studies in rats at 20 mg/kg indicated extensive systemic clearance and tissue distribution, leading to a half-life of 6.6 h.
• CAS Number: [2454246-18-3]
• MW: 545.109
• SMILES: ClC1C=CC(=C(C=1)CN(C(CC1=CSC=C1)=O)CCC1C=CC(=CC=1)S(NCC#C)(=O)=O)OCCC
• Formula: C₂₇H₂₉CLN₂O₄S₂
• Note: For research use only
• Expiration Date: 12 months from date of receipt.