YKL-5-124 TFA

• Catalog Number: orb1983579
• Category: Small Molecules
• Description: YKL-5-124 TFA
• CAS Number: 2748220-93-9
• MW: 629.63
• Formula: C₃₀H₃₄F₃N₇O₅
• Biological Activity: YKL-5-124 TFA, a potent and selective irreversible covalent inhibitor of CDK7, demonstrates IC50 values of 53.5 nM for CDK7 and 9.7 nM for the CDK7/Mat1/CycH complex. It exhibits over 100-fold selectivity for CDK7 over CDK9 and CDK2, while showing no activity against CDK12 and CDK13. This compound effectively induces cell-cycle arrest, inhibits E2F-driven gene expression, and has minimal impact on the phosphorylation status of RNA polymerase II.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.