YJ1206

• Catalog Number: orb2695706
• Category: Small Molecules
• Description: YJ1206 is a selective CDK12/CDK13 PROTAC degrader with oral activity, demonstrating an IC50 of 12.55 nM in VCaP cells. It enhances DNA damage, induces apoptosis, and promotes tumor regression in a castration-resistant prostate cancer PDX (patient-derived xenograft) mouse model derived from original site WA74. Additionally, YJ1206 acts synergistically with AKT pathway inhibitors to suppress in vivo tumor growth.
• CAS Number: 3053716-98-3
• MW: 894.01
• SMILES: O=C1C=2C(C(=O)N1C3C(=O)NC(=O)CC3)=CC(F)=C(C2)N4CCC(CC4)N5CCN(CC5)C6=CC=C(N(C(NCC7=CC=CC=C7)=O)[C@@H]8CC[C@@H](NC9=NC%10=C(C=N9)C=CC=C%10)CC8)C=N6
• Formula: C₄₉H₅₂FN₁₁O₅
• Storage: -20°C
• Note: For research use only
• Expiration Date: 12 months from date of receipt.