You have no items in your shopping cart.
You have no items in your shopping cart.
Catalog Number | orb1089362 |
---|---|
Category | Small Molecules |
Description | XL177A is a potent USP7 inhibitor. XL177A irreversibly inhibits USP7 with sub-nM potency and selectivity across the human proteome. Evaluation of the cellular effects of XL177A reveals that selective USP7 inhibition suppresses cancer cell growth predominantly through a p53-dependent mechanism: XL177A specifically upregulates p53 transcriptional targets transcriptome-wide, hotspot mutations in TP53 but not any other genes predict response to XL177A across a panel of ~500 cancer cell lines, and TP53 knockout rescues XL177A-mediated growth suppression of TP53 wild-type (WT) cells. |
CAS Number | [188719-92-8] |
MW | 130.1882 |
SMILES | O([H])/N=C(/C([H])([H])C([H])([H])C([H])(C([H])([H])[H])C([H])([H])[H])\N([H])[H] |
Formula | C6H14N2O |
Note | For research use only |
Expiration Date | 12 months from date of receipt. |
98.75% | |
2417089-74-6 | |
861.47 | |
C48H57ClN8O5 |
Filter by Rating