Xeruborbactam

• Catalog Number: orb1910375
• Category: Small Molecules
• Description: Xeruborbactam (QPX7728) is an ultrabroad-spectrum beta-lactamase inhibitor, inhibits class A extended-spectrum beta-lactamases with IC50 of 1-3 nM, carbapenemases such as KPC (IC50, 2.9 nM), class C P99 (IC50, 22 nM).QPX7728 displays a remarkably broad spectrum of inhibition, including class B and class D enzymes.QPX7728 is also a potent inhibitor of class D carbapenemases such as OXA-48 from Enterobacteriaceae and OXA enzymes from Acinetobacter baumannii (OXA-23/24/58, IC50 range, 1 to 2 nM) as well as MBLs such as NDM-1 (IC50, 55 ± 25 nM), VIM-1 (IC50, 14 ± 4 nM), and IMP-1 (IC50, 610 ± 70 nM).QPX7728 restored the potency of meropenem against carbapenem-resistant Enterobacterales (CRE), with the meropenem MIC90 decreasing from > 64 μg/ml to 0.5 μg/ml for QPX7728 (8 μg/ml).
• CAS Number: [2170834-63-4]
• MW: 221.9775
• SMILES: FC1C([H])=C([H])C2=C(C=1C(=O)O[H])OB([C@]1([H])C([H])([H])[C@@]12[H])O[H]
• Formula: C₁₀H₈BFO₄
• Note: For research use only
• Expiration Date: 12 months from date of receipt.