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WYE-687 dihydrochloride
Catalog Number: orb1745010
| Catalog Number | orb1745010 |
|---|---|
| Category | Small Molecules |
| Description | WYE-687 dihydrochloride is an ATP-competitive inhibitor of mTOR, demonstrating potent activity with an IC50 value of 7 nM. It effectively suppresses the activation of both mTORC1 and mTORC2. Additionally, WYE-687 exhibits inhibitory effects on PI3Kα and PI3Kγ, with IC50 values of 81 nM and 3.11 μM, respectively. |
| CAS Number | 1702364-87-1 |
| Purity | 98.00% |
| MW | 601.53 |
| SMILES | Cl.Cl.O=C(OC)NC=1C=CC(=CC1)C=2N=C3C(C=NN3C4CCN(CC=5C=NC=CC5)CC4)=C(N2)N6CCOCC6 |
| Formula | C28H34Cl2N8O3 |
| Biological Activity | WYE-687 dihydrochloride is an ATP-competitive inhibitor of mTOR, demonstrating potent activity with an IC 50 value of 7 nM. It effectively suppresses the activation of both mTORC1 and mTORC2. Additionally, WYE-687 exhibits inhibitory effects on PI3Kα and PI3Kγ, with IC 50 values of 81 nM and 3.11 μM, respectively. |
| Storage | -20°C |
| Note | For research use only |
| Expiration Date | 12 months from date of receipt. |
