WYE-354

• Catalog Number: orb1300518
• Category: Small Molecules
• Description: WYE-354
• CAS Number: 1062169-56-5
• Purity: 98.31%
• MW: 495.53
• SMILES: C(OC)(=O)N1CCC(N2C=3C(=C(N=C(N3)C4=CC=C(NC(OC)=O)C=C4)N5CCOCC5)C=N2)CC1
• Formula: C₂₄H₂₉N₇O₅
• Biological Activity: WYE-354(IC50=5 nM) is an effective, selective and ATP-competitive mTOR inhibitor. It blocks mTORC2/P-AKT(S473) and mTORC1/P-S6K(T389), not P-AKT(T308). The selectivity for mTOR is higher than PI3Kα (>100-fold) and PI3Kγ (>500-fold).
• Storage: Store at -20°C for 12 months.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.