VU0463271

• Catalog Number: orb1307613
• Category: Small Molecules
• Description: VU0463271
• CAS Number: 1391737-01-1
• Purity: 99.75%
• MW: 382.5
• SMILES: N(C(CSC1=CC=C(N=N1)C2=CC=CC=C2)=O)(C3CC3)C4=NC(C)=CS4
• Formula: C₁₉H₁₈N₄OS₂
• Biological Activity: VU0463271 is a potent and selective antagonist of the neuronal-specific potassium-chloride cotransporter 2 (KCC2), with an IC50 of 61 nM and > 100-fold selectivity versus the closely related Na-K-2Cl cotransporter 1 (NKCC1) and no activity in a larger panel of GPCRs, ion channels, and transporters.
• Storage: Store at -20°C for 12 months.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.