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VU0134992
Catalog Number: orb746470
| Catalog Number | orb746470 |
|---|---|
| Category | Small Molecules |
| Description | VU0134992 (VU 0134992) is a potent, selective blocker of the inward rectifier potassium channel Kir4.1 (KCNJ10) with IC50 of 0.97 uM in whole-cell patch clamp electrophysiology assays; displays 9-fold selectivity for homomeric Kir4.1 over Kir4.1/5.1 concatemeric channels (IC50=9 uM) at -120 mV; VU0134992 is greater than 30-fold selective for Kir4.1 over Kir1.1, Kir2.1, and Kir2.2, is weakly active toward Kir2.3, Kir6.2/SUR1, and Kir7.1, and is equally active toward Kir3.1/3.2, Kir3.1/3.4, and Kir4.2 in Tl+ flux assays; causes dose-dependent diuresis, natriuresis, and kaliuresis in rats after oral treatment; VU0134992 represents the first in vivo-active tool compound for probing the therapeutic potential of Kir4.1 as a novel diuretic target for the treatment of hypertension. |
| CAS Number | [755002-90-5] |
| MW | 411.384 |
| SMILES | O=C(NC1CC(C)(C)NC(C)(C)C1)COC2=CC=C(C(C)C)C=C2Br |
| Formula | C20H31BrN2O2 |
| Note | For research use only |
| Expiration Date | 12 months from date of receipt. |
VU0134992 [orb1298990]
99.16%
755002-90-5
411.38
C20H31BrN2O2
1 mg, 5 mg, 10 mg, 25 mg, 2 mg, 100 mg, 50 mg, 500 mg, 1 mL*10mM (in DMSO)VU0134992 hydrochloride [orb1308951]
100%
1052515-91-9
447.84
C20H32BrClN2O2
5 mg, 50 mg, 100 mg, 10 mg, 25 mg, 2 mg, 1 mL*10mM (in DMSO)
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