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Catalog Number | orb654737 |
---|---|
Category | Small Molecules |
Description | USP25 and 28 inhibitor AZ-1 (AZ1) is a potent, selective, dual USP25/28 inhibitor with IC50 of 0.7/0.6 uM, respectively; shows a high degree of selectivity over other deubiquitinases (USP4,7 etc.); demonstrates target engagement against both USP25 and USP28 in cells, elicits modulation of both the total levels and the half-life of the c-Myc oncoprotein in cells, and also induces apoptosis and inhibits cell viability in a range of cancer cell lines. |
CAS Number | [2165322-94-9] |
MW | 422.218 |
SMILES | C(O)CNCC1=CC(Br)=CC=C1OCC1=CC=C(F)C(C(F)(F)F)=C1 |
Formula | C17H16BrF4NO2 |
Note | For research use only |
Expiration Date | 12 months from date of receipt. |
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