USP10 inhibitor Wu-5

• Catalog Number: orb2279755
• Category: Small Molecules
• Description: USP10 inhibitor Wu-5 (Wu-5) is a novel small molecule USP10 inhibitor inducing the degradation of FLT3-mutated protein, directly interacts and inactivates USP10, the deubiquitinase for FLT3-ITD in vitro (IC50=8.3 uM) and in FLT3-ITD-positive AML cells.Wu-5 selectively inhibited the viability of FLT3 inhibitor-sensitive (MV4-11, Molm13) and -resistant (MV4-11R) FLT3-ITD-positive AML cells with IC50 of 3.794, 5.056, and 8.386 uM, respectively.Wu-5 (1-10 μM) dose-dependently induced apoptosis of MV4-11, Molm13, and MV4-11R cells through the proteasome-mediated degradation of FLT3-ITD.Combined treatment of Wu-5 and crenolanib produced synergistic cell death in FLT3-ITD-positive cells via the reduction of both FLT3 and AMPKα proteins.
• CAS Number: [2630378-05-9]
• MW: 351.3312232
• SMILES: C1(C(OCC)=O)SC(OC2=CC=C(C(OC)=O)C=C2)=C([N+]([O-])=O)C=1
• Formula: C₁₅H₁₃NO₇S
• Note: For research use only
• Expiration Date: 12 months from date of receipt.