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Urocortin III (human)
Catalog Number: orb1981279
| Catalog Number | orb1981279 |
|---|---|
| Category | Small Molecules |
| Description | Urocortin III (human) is a corticotropin-releasing factor (CRF)-related peptide that primarily interacts with and activates the CRF receptor type 2 (CRF-R2), showing a specific distribution in the central nervous system and periphery. It selectively binds to type 2 CRF receptors with dissociation constants (Ki values) of 13.5 nM for mouse CRF2β, 21.7 nM for rat CRF2α, and > 100 nM for human CRF1, indicating a strong preference for CRF-R2 over CRF1. Additionally, Urocortin III (human) plays a crucial role in the somatostatin-dependent negative feedback mechanism regulating the secretion of Insulin (human). |
| CAS Number | 357952-09-1 |
| Purity | 98.00% |
| MW | 4137.93 |
| Formula | C185H307N53O50S2 |
| Biological Activity | Urocortin III (human) is a corticotropin-releasing factor (CRF)-related peptide that primarily interacts with and activates the CRF receptor type 2 (CRF-R2), showing a specific distribution in the central nervous system and periphery. It selectively attaches to type 2 CRF receptors, exhibiting dissociation constants (Ki values) of 13.5 nM for mouse CRF2β, 21.7 nM for rat CRF2α, and > 100 nM for human CRF1, indicating a strong preference for CRF-R2 over CRF1. Furthermore, Urocortin III (human) plays a crucial role in the somatostatin-dependent negative feedback mechanism that regulates the secretion of Insulin (human). |
| Storage | -20°C |
| Note | For research use only |
| Expiration Date | 12 months from date of receipt. |
Human UCN3 Protein [orb1477315]
Greater than 90% as determined by SDS-PAGE.
20.1 kDa
E.coli
1 mg, 20 μg, 100 μgHuman UCN3 ELISA Kit [orb405530]
Human
6.25 pg/mL-400 pg/mL
1.56 pg/mL
48 T, 96 T, 10 x 96 T, 5 x 96 T, 24 TRecombinant Human Urocortin-3 (UCN3) [orb1674693]
Greater than 85% as determined by SDS-PAGE.
17.7 kDa
E.coli
1 mg, 100 μg, 20 μg
