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Catalog Number | orb1307642 |
---|---|
Category | Small Molecules |
Description | TX1-85-1 |
CAS Number | 1603845-32-4 |
Purity | 98.12% |
MW | 580.68 |
SMILES | CC(=O)N1CCN(CC1)C1CCC(CC1)n1nc(-c2ccc(Oc3ccccc3)c(NC(=O)C=C)c2)c2c(N)ncnc12 |
Formula | C32H36N8O3 |
Biological Activity | TX1-85-1 induces partial degradation of Her3 protein and attenuates Her3-dependent signaling. TX1-85-1 is an irreversible Her3 inhibitor (IC50: 23 nM). TX1-85-1 is also the first selective Her3 ligand, which forms a covalent bond with Cys721 located in the ATP-binding site of Her3. |
Storage | -20°C |
Note | For research use only |
Expiration Date | 12 months from date of receipt. |
> 98% (HPLC) | |
1603845-32-4 |
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