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Catalog Number | orb1818865 |
---|---|
Category | Small Molecules |
Description | TTC352 is a synthetic selective estrogen mimic acts as estrogen receptor (ER) partial agonist for the treatment of endocrine-resistant breast cancer.TTC 352 yields an H-bond with Glu353, allows Asp351-to-helix 12 (H12) interaction, sealing ERα's ligand-binding domain, recruiting E2-enriched coactivators, and triggering rapid ERα-induced unfolded protein response (UPR) and apoptosis.TTC-352 is a less potent full estrogen agonist compared to E2, allowing H12 to seal the LBD, which recruits many E2-enriched coactivators, and induces rapid ERα-mediated UPR and apoptosis. |
CAS Number | [1607819-68-0] |
MW | 352.3788278 |
SMILES | S1C(=C(C2C=CC(=CC=2)F)C2C=CC(=CC1=2)O)OC1C=CC(=CC=1)O |
Formula | C20H13FO3S |
Note | For research use only |
Expiration Date | 12 months from date of receipt. |
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