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Catalog Number | orb1822773 |
---|---|
Category | Antibodies |
Description | It reacts with a 75kDa melanocyte-specific gene product, identified as Tyrosinase-related protein-1 (TRP-1). It is involved in melanin synthesis. TRP1 is present on the melanosomal membranes of melanoma, normal melanocytes and nevi. Recent evidence suggests that TRP-1 is involved in maintaining stability of tyrosinase protein and modulating its catalytic activity. TRP-1 is also involved in maintenance of melanosome ultrastructure and affects melanocyte proliferation and cell death. |
Species/Host | Rabbit |
Clonality | Recombinant |
Clone Number | TYRP1/8313R |
Tested applications | IHC-P |
Reactivity | Human |
Isotype | Rabbit IgG, kappa |
Immunogen | A recombinant partial protein sequence (within amino acids 200-400) from the human protein was used as the immunogen for the Tyrosinase-Related Protein-1 antibody. |
Dilution range | Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT |
Conjugation | Unconjugated |
Formula | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide |
Hazard Information | This Tyrosinase-Related Protein-1 antibody is available for research use only. |
UniProt ID | P17643 |
Storage | Aliquot the Tyrosinase-Related Protein-1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles. |
Note | For research use only |
Expiration Date | 12 months from date of receipt. |
IHC staining of FFPE human melanoma tissue with Tyrosinase-Related Protein-1 antibody (clone TYRP1/8313R). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
SDS-PAGE analysis of purified, BSA-free Tyrosinase-Related Protein-1 antibody (clone TYRP1/8313R) as confirmation of integrity and purity.
ELISA, IHC-P | |
Human | |
Rabbit | |
Recombinant | |
Unconjugated |
ELISA, IHC-P | |
Human | |
Mouse | |
Monoclonal | |
Unconjugated |
ELISA, IHC-P | |
Human | |
Mouse | |
Monoclonal | |
Unconjugated |
ELISA, IHC-P | |
Human | |
Mouse | |
Monoclonal | |
Unconjugated |
ELISA, IHC-P | |
Human | |
Mouse | |
Monoclonal | |
Unconjugated |
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