TRP1 / Tyrosinase-Related Protein-1 Antibody

• Catalog Number: orb1822772
• Category: Antibodies
• Description: It reacts with a 75kDa melanocyte-specific gene product, identified as Tyrosinase-related protein-1 (TRP-1). It is involved in melanin synthesis. TRP1 is present on the melanosomal membranes of melanoma, normal melanocytes and nevi. Recent evidence suggests that TRP-1 is involved in maintaining stability of tyrosinase protein and modulating its catalytic activity. TRP-1 is also involved in maintenance of melanosome ultrastructure and affects melanocyte proliferation and cell death.
• Species/Host: Rabbit
• Clonality: Recombinant
• Clone Number: TYRP1/8313R
• Tested applications: IHC-P
• Reactivity: Human
• Isotype: Rabbit IgG, kappa
• Immunogen: A recombinant partial protein sequence (within amino acids 200-400) from the human protein was used as the immunogen for the Tyrosinase-Related Protein-1 antibody.
• Dilution range: Immunohistochemistry (FFPE): 1-2ug/ml for 30 min at RT
• Conjugation: Unconjugated
• Formula: 1 mg/ml in 1X PBS; BSA free, sodium azide free
• Hazard Information: This Tyrosinase-Related Protein-1 antibody is available for research use only.
• UniProt ID: P17643
• Storage: Aliquot the Tyrosinase-Related Protein-1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.

IHC staining of FFPE human melanoma tissue with Tyrosinase-Related Protein-1 antibody (clone TYRP1/8313R). HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

SDS-PAGE analysis of purified, BSA-free Tyrosinase-Related Protein-1 antibody (clone TYRP1/8313R) as confirmation of integrity and purity.