TPX-0131

• Catalog Number: orb1685301
• Category: Small Molecules
• Description: TPX-0131
• CAS Number: 2648641-36-3
• MW: 447.41
• SMILES: C(F)(F)[C@H]1N2C=3C(=CN4C(N3)=C(C=N4)C(=O)NC(C)(C)COC=5C(C2)=CC(F)=CC5)OC1
• Formula: C₂₁H₂₀F₃N₅O₃
• Biological Activity: TPX-0131 is a potent, selective, CNS-penetrant and orally active inhibitor of wild-type ALK ( IC 50 of 1.4 nM) and is potent against ALK-resistant mutation, e.g. G1202R ( IC 50 of 0.3 nM), L1196M ( IC 50 of 0.3 nM). TPX-0131 has strong antitumor activities [1].
• Note: For research use only
• Expiration Date: 12 months from date of receipt.