TPX-0131

• Catalog Number: orb1089576
• Category: Small Molecules
• Description: TPX-0131 is a potent, selective, CNS-penetrant and orally active inhibitor of wild-type ALK (IC50 of 1.4 nM) and ALK-resistant mutation, e.g. G1202R (IC50 of 0.3 nM), L1196M (IC50 of 0.3 nM). TPX-0131 has strong antitumor activities.
• CAS Number: [2648641-36-3]
• MW: 447.41
• SMILES: FC([C@H]1N2C3=NC4=C(C(NC(C)(COC5=CC=C(F)C=C5C2)C)=O)C=NN4C=C3OC1)F
• Formula: C₂₁H₂₀F₃N₅O₃
• Note: For research use only
• Expiration Date: 12 months from date of receipt.