Tolebrutinib

• Catalog Number: orb1298347
• Category: Small Molecules
• Description: Tolebrutinib
• CAS Number: 1971920-73-6
• Purity: 99.20%
• MW: 455.51
• SMILES: NC1=C2C(N(C(=O)N2C3=CC=C(OC4=CC=CC=C4)C=C3)[C@H]5CN(C(C=C)=O)CCC5)=CC=N1
• Formula: C₂₆H₂₅N₅O₃
• Biological Activity: Tolebrutinib (PRN2246) is a potent, selective, orally active and brain-penetrant Bruton tyrosine kinase (BTK) inhibitor(IC50s of 0.4 and 0.7 nM in Ramos B cells and in HMC microglia cells, respectively). It exhibits efficacy in central nervous system immunity. Tolebrutinib can be used for the research of multiple sclerosis (MS).
• Storage: Store at -20°C for 12 months.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.