TNFR1/CD120a/TNFRSF1A Protein, Cynomolgus, Recombinant (His)

• Catalog Number: orb1960334
• Category: Proteins
• Description: Tumour necrosis factor alpha (TNF-α) is a pleiotropic cytokine with both injurious and protective functions, which are thought to diverge at the level of its two cell surface receptors, TNFR1 and TNFR2. In the setting of acute injury, selective inhibition of TNFR1 is predicted to attenuate the cell death and inflammation associated with TNF-α, while sparing or potentiating the protective effects of TNFR2 signalling.
• Tag: C-His
• Purity: 98.00%
• MW: 21.62 kDa (predicted). Due to glycosylation, the protein migrates to 32-42 kDa based on Tris-Bis PAGE result.
• UniProt ID: A0A7N9CVF2
• Expression System: HEK293 Cells
• Biological Origin: Cynomolgus
• Biological Activity: Tumour necrosis factor alpha (TNF-α) is a pleiotropic cytokine with both injurious and protective functions, which are thought to diverge at the level of its two cell surface receptors, TNFR1 and TNFR2. In the setting of acute injury, selective inhibition of TNFR1 is predicted to attenuate the cell death and inflammation associated with TNF-α, while sparing or potentiating the protective effects of TNFR2 signalling.
• Expression Region: Leu30-Thr211
• Storage: -20°C
• Note: For research use only
• Application notes: Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
• Expiration Date: 6 months from date of receipt.