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Catalog Number | orb348885 |
---|---|
Category | Antibodies |
Description | Rabbit monoclonal antibody to TNF alpha |
Species/Host | Human |
Clonality | Monoclonal |
Clone Number | CDP 571 (Humicade) |
Tested applications | ELISA |
Reactivity | Human |
Isotype | IgG |
Immunogen | Human TNF-alpha |
Concentration | 1 mg/ml |
Purity | Purified |
Conjugation | Unconjugated |
Target | TNF alpha |
UniProt ID | P01375 |
Storage | Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C. |
Buffer/Preservatives | PBS with 0.02% Proclin 300. |
Alternative names | TNFA; Tumour necrosis factor superfamily member 2; Read more... |
Note | For research use only |
Application notes | The antibody binds specifically to TNF-alpha, a pro-inflammatory cytokine which stimulates release of other cytiokines e.g. IL-1, IL-6 and GM-CSF as well as secretion of ICAM-1 and VCAM-1 from endothelial cells. It stimulates acute phase responses and acts as a chemoattractant for NK cells and monocytes/macrophages. The antibody reached Phase II clinical trials with Celltech, UCB. |
Expiration Date | 12 months from date of receipt. |
Stephens, S. et al. Comprehensive pharmacokinetics of a humanized antibody and analysis of residual anti-idiotypic responses Immunology, 85, 668-674 (1995)
ICC, IF, IHC-P | |
Human, Mouse, Rat | |
Rabbit | |
Polyclonal | |
Unconjugated |
ELISA, IF, IHC, WB | |
Human | |
Rabbit | |
Polyclonal | |
Unconjugated |
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