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Catalog Number | orb1089442 |
---|---|
Category | Small Molecules |
Description | Thailanstatin A is an ultra-potent inhibitor of eukaryotic RNA splicing (IC50=650 nM). Thailanstatin A exerts effects via non-covalent binding to the SF3b subunit of the U2 snRNA subcomplex of the spliceosome and shows low-nM to sub-nM IC50s against multiple cancer cell lines. Thailanstatin A, a payload for ADCs, is conjugated to the lysines on trastuzumab yielding “linker-less” ADC. |
CAS Number | [1426953-21-0] |
MW | 535.62644 |
SMILES | CC(=O)OC(C)\C=C\C(=O)NC1C(C)OC(C\C=C(/C)\C=C\C2C(O)C3(CC(CC(O)=O)O2)OC3)C(C)C1 |
Formula | C28H41NO9 |
Note | For research use only |
Expiration Date | 12 months from date of receipt. |
1609108-96-4 | |
1230.45 | |
C63H91N9O16 |
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