TH263

• Catalog Number: orb654622
• Category: Small Molecules
• Description: TH-263 is an inactive analog control for the type III allosteric LIM-kinase (LIMK) inhibitors TH-257, TH-255 and TH-251. LIM kinases belong to the family of cytoplasmic tyrosine-like kinases with dual specificity (serine/threonine and tyrosine). However, known LIMK substrate are usually phosphorylated at serine and threonine residues LIM kinases comprises LIM kinase 1 (LIMK1) and LIM kinase 2 (LIMK2) which show 50% sequence identity in human. Both LIMK1 and LIMK2 present with a unique domain organization containing two N-terminal LIM domains, a PDZ domain, a proline/serine-rich domain and a C-terminal kinase domain.
• CAS Number: [313520-94-4]
• MW: 380.46
• SMILES: O=C(C1C=CC(S(=O)(NCC2C=CC=CC=2)=O)=CC=1)NCC1C=CC=CC=1
• Formula: C₂₁H₂₀N₂O₃S
• Note: For research use only
• Expiration Date: 12 months from date of receipt.