TH1020

• Catalog Number: orb691996
• Category: Small Molecules
• Description: TH1020 is a novel Toll-Like Receptor 5 (TLR5)/Flagellin Complex Inhibitor with promising activity (IC50 =0.85±0.12?μm) and specificity. TH1020 was shown to repress the expression of downstream TNF-α signaling pathways mediated by the TLR5/flagellin complex formation. Based on molecular docking simulation, TH1020 is suggested to compete with flagellin and disrupt its association with TLR5. TH1020 provides a much-needed molecular probe for studying this important protein-protein interaction and a lead compound for identifying novel therapeutics targeting TLR5.
• CAS Number: [1841460-82-9]
• MW: 453.54
• SMILES: C12=NC=NC(SC3=NN=C(N3CC4=CC=CC=C4)C5=CC=NC=C5)=C1SC6=NC=CC=C62
• Formula: C₂₃H₁₅N₇S₂
• Note: For research use only
• Expiration Date: 12 months from date of receipt.