TET1 (C2) Antibody, Rabbit Polyclonal

SKU: orb67230

Description

Rabbit polyclonal to TET1.TET1 is a methylcytosine dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC). Methylation at the C5 position ofcytosine bases is an epigenetic modification of the mammalian genome which plays an important rolein transcriptional regulation. TET1 might initiate a process leading to cytosine demethylation throughdeamination into 5-hydroxymethyluracil (5hmU) and subsequent replacement by unmethylatedcytosine by the base excision repair system. TET1 preferentially binds to CpG-rich sequences atpromoters of both transcriptionally active and polycomb-repressed genes. By controlling the levels of5mC and 5hmC at gene promoters, it may regulate the gene silencing induced by cytosinemethylation. It has been shown that TET1 plays an important role in embryonic stem cellsmaintenance and regulating the balance between pluripotency and lineage commient.

Images & Validation

• Tested Applications: ChIP, WB
• Dilution range: WB:1:500-1:1000, ChIP: 1:100- 1:200
• Reactivity: Human, Mouse

Key Properties

• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: C-terminal region of human TET1
• Molecular Weight: 235
• Purity: Affinity purification

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Buffer/Preservatives: 0.01% NaN3
• Disclaimer: For research use only

Alternative Names

anti-TET1 antibody,anti-Methylcytosine dioxygenase TET1 antibody,anti-CXXCtype zinc finger protein 6 antibody,anti-Leukemiaassociated protein with a CXXC domain antibody,anti-Teneleven translocation 1 gene protein antibody,anti-CXXC6 antibody,anti-KIAA1676 antibody,anti-LCX antibody

Chromatography analysis of human Jurkat using TET1 antibody

Western blot analysis of total cell extracts from a: human iPS; b: human Jurkat; c,d: mouse thymus; e: mouse fetal brain, using TET1 antibody.

Quick Database Links

UniProt

Q8NFU7