Tazemetostat trihydrochloride

• Catalog Number: orb1989269
• Category: Small Molecules
• Description: Tazemetostat trihydrochloride
• CAS Number: 1403255-00-4
• MW: 682.12
• SMILES: O=C(C1=CC(C2=CC=C(CN3CCOCC3)C=C2)=CC(N(C4CCOCC4)CC)=C1C)NCC5=C(C)C=C(C)NC5=O.Cl.Cl.Cl
• Formula: C₃₄H₄₇Cl₃N₄O₄
• Biological Activity: Tazemetostat trihydrochloride is a selective and orally available inhibitor of EZH2 (IC50: 4 nM for rat EZH2). It inhibits the activity of human PRC2-containing wild-type EZH2 (Ki: 2.5 nM). It inhibits EZH2 (IC50s: 11 and 16 nM in peptide assay and nucleosome assay).
• Note: For research use only
• Expiration Date: 12 months from date of receipt.