TAK-960 dihydrochloride

• Catalog Number: orb1745011
• Category: Small Molecules
• Description: TAK-960 dihydrochloride
• MW: 634.52
• SMILES: CN1CCC(CC1)NC(=O)C2=CC(=C(C=C2F)NC3=NC=C4C(=N3)N(CC(C(=O)N4C)(F)F)C5CCCC5)OC.Cl.Cl
• Formula: C₂₇H₃₆Cl₂F₃N₇O₃
• Biological Activity: TAK-960 dihydrochloride is an orally administered, selective polo-like kinase 1 (PLK1) inhibitor, exhibiting a potent IC 50 of 0.8 nM. It also targets PLK2 and PLK3 with IC 50 values of 16.9 and 50.2 nM, respectively. This compound effectively inhibits the proliferation of a broad range of cancer cell lines and demonstrates substantial efficacy against various tumor xenografts.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.