T16Ainh-A01

• Catalog Number: orb757638
• Category: Small Molecules
• Description: T16Ainh-A01 is an inhibitor of the calcium-activated chloride channel TMEM16A, inhibits Ca2+-activated Cl? channel (CACC) activity in TMEM16A-transfected FRT cells with IC50 of 1 uM; T16Ainh-A01 (1-30 uM) inhibited single calcium (Ca2+)-activated chloride (Cl?) channels and whole cell currents activated by 500 nM free Ca2+; T16Ainh-A01 relaxed mouse thoracic aorta pre-contracted with methoxamine with an IC50 of 1.6 uM and suppressed the methoxamine concentration-effect curve; blocks calcium-activated chloride channels in vascular smooth muscle cells and relaxes murine and human blood vessels.
• CAS Number: [552309-42-9]
• MW: 416.514
• SMILES: COC1C=CC(C2=CSC(NC(CSC3NC(C)=C(CC)C(=O)N=3)=O)=N2)=CC=1
• Formula: C₁₉H₂₀N₄O₃S₂
• Note: For research use only
• Expiration Date: 12 months from date of receipt.