Sulfaphenazole

• Catalog Number: orb1302751
• Category: Small Molecules
• Description: Sulfaphenazole
• CAS Number: 526-08-9
• Purity: 98.83%
• MW: 314.36
• SMILES: N(S(=O)(=O)C1=CC=C(N)C=C1)C=2N(N=CC2)C3=CC=CC=C3
• Formula: C₁₅H₁₄N₄O₂S
• Biological Activity: Sulfaphenazole (Plisulfan) is an inhibitor of CYP2C9 (Ki: 0.3 μM) that demonstrates at least 100-fold selectivity over other CYP450 isoforms (Ki: 63/29 μM for CYP2C8/CYP2C18, respectively, and no activity at CYP1A1, CYP1A2, CYP3A4, CYP2C19). At 10 μM, sulfaphenazole has been shown to inhibit endothelium-derived hyperpolarizing factor synthase, a CYP450 isozyme in the porcine coronary artery homologous to CYP2C8/9 that generates reactive oxygen species in coronary endothelial cells and modulates vascular tone and homeostasis.
• Storage: Store at -20°C for 12 months.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.