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Catalog Number | orb1692257 |
---|---|
Category | Small Molecules |
Description | STING Agonist 1a |
CAS Number | 652142-94-4 |
Purity | 98% |
MW | 396.23 |
SMILES | ClC=1C=2N(C(=NN2)C3=CC4=C(N=C3Cl)C=CC(OC)=C4)C=5C(N1)=CC=CC5 |
Formula | C19H11Cl2N5O |
Biological Activity | STING agonist 1a is an agonist of stimulator of interferon genes (STING).1It induces expression of an IRF-inducible SEAP reporter gene in a cell-based assay (EC50= 16.77 μM). STING agonist 1a (12.5-100 μM) induces expression of IFN-β, IL-6, and chemokine (C-X-C motif) ligand 10 (CXCL10) in THP-1 cells, an effect that can be reversed by STING knockout or the STING inhibitor H-151 . |
Storage | Store at -20°C for 12 months. |
Note | For research use only |
Expiration Date | 12 months from date of receipt. |
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