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Catalog Number | orb1692259 |
---|---|
Category | Small Molecules |
Description | STING Agonist 12b |
CAS Number | 2411100-70-2 |
Purity | 98% |
MW | 253.3 |
SMILES | O=C1C=2C(NC=3C1=CC=C(C)C3C)=CC=C(OC)C2 |
Formula | C16H15NO2 |
Biological Activity | STING agonist 12b is an agonist of stimulator of interferon genes (STING).1It binds to STING (Kd= 26.4 μM) and induces interferon reporter gene expression in cells expressing human or mouse STING (EC50s = 7.45 and 10.23 μM, respectively). STING agonist 12b (40 μM) induces expression of TNF-a, IL-6, IP-10, and IL-1b in THP-1 cells. |
Storage | Store at -20°C for 12 months. |
Note | For research use only |
Expiration Date | 12 months from date of receipt. |
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