SRT1720 Hydrochloride

• Catalog Number: orb322204
• Category: Small Molecules
• Description: SRT1720 is an inhibitor of sirtuin 3 (SIRT3) and activator of sirtuin 1 (SIRT1); sirtuins are considered class III histone deacetylases (HDACs). SRT1720 exhibits nephroprotective, anti-aging, anti-inflammatory, and pro-angiogenic activities. SRT1720 binds the acetyl-Lys site on sirtuins rather than the NAD+ site. In animal models of kidney ischemia/reperfusion injury, SRT1720 improves renal tubular pathology and overall renal function. In animal models fed high fat diets, SRT1720 delays the onset of metabolic diseases and decreases levels of pro-inflammatory cytokines, extending animal lifespan. In animal models of macular degeneration, this compound suppresses activation of NF-κB and release of IL-6, IL-8, and MMP-9, decreasing amyloid-β (Aβ)-induced retinal pigment epithelial barrier disruption. Additionally, SRT1720 increases VEGF secretion and promotes migration and metastasis of breast cancer cells in vitro and in vivo.
• CAS Number: 1001645-58-4
• Purity: ≥98%
• MW: 506.02
• SMILES: c1ccc(c(c1)c2cn3c(csc3n2)CN4CCNCC4)NC(=O)c5cnc6ccccc6n5.Cl
• Formula: C₂₅H₂₃N₇OS HCl
• Hazard Information: UN Number: Not dangerous goods
• Solubility (25°C): DMSO 38 mg/mL (75.09 mM) Water Insoluble Ethanol Insoluble
• Storage: Storage Temp: -20°C
• Alternative names: STR-1720 HCl salt
• Note: For research use only
• Expiration Date: 12 months from date of receipt.

Chemical structure of SRT1720 Hydrochloride