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SR-717
Catalog Number: orb1089392
| Catalog Number | orb1089392 |
|---|---|
| Category | Small Molecules |
| Description | SR-717 is an agonist of stimulator of interferon genes STING for treating cancer. SR-717 demonstrates broad interspecies and interallelic specificity. SR-717 functions as a direct cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) mimetic that induces the same "closed" conformation of STING. SR-717 displayed antitumor activity; promoted the activation of CD8+ T, natural killer, and dendritic cells in relevant tissues; and facilitated antigen cross-priming. SR-717 also induced the expression of clinically relevant targets, including programmed cell death 1 ligand 1 (PD-L1), in a STING-dependent manner. |
| CAS Number | [2375420-34-9] |
| MW | 345.26 |
| SMILES | O=C(O)C1=CC(F)=C(F)C=C1NC(C2=NN=C(N3C=CN=C3)C=C2)=O |
| Formula | C15H9F2N5O3 |
| Note | For research use only |
| Expiration Date | 12 months from date of receipt. |
SR-717 [orb1298740]
99.98%
2375421-09-1
351.19
C15H8F2LiN5O3
50 mg, 100 mg, 2 mg, 5 mg, 10 mg, 25 mg, 1 ml x 10 mm (in DMSO)
