Sp-Adenosine-5'-O-(1-thiotriphosphate) sodium

• Catalog Number: orb2276825
• Category: Small Molecules
• Description: Sp-Adenosine-5'-O-(1-thiotriphosphate) (Sp-ATP-α-S), an isomer of the ATP-α-S sulfur-containing nucleotide derivative and a purinergic P2Y1 receptor agonist, effectively increases calcium mobilization in HEK293 cells harboring the P2Y1 receptor with an EC50 of 9.4 nM for the human receptor. It also inhibits ADP-induced human isolated platelet aggregation with a Ki value of 4 μM and prompts relaxation in carbamoylcholine-tightened guinea pig taenia coli, achieving an EC50 of 426 nM.
• Purity: 98.00%
• MW: 611.18
• SMILES: O[C@@H]1[C@@H](CO[P@@](OP(OP([O-])([O-])=O)([O-])=O)([S-])=O)O[C@@H](N2C3=NC=NC(N)=C3N=C2)[C@@H]1O.[Na+].[Na+].[Na+].[Na+]
• Formula: C₁₀H₁₂N₅O₁₂P₃S.4Na
• Biological Activity: Sp-Adenosine-5'-O-(1-thiotriphosphate) (Sp-ATP-α-S), an isomer of the ATP-α-S sulfur-containing nucleotide derivative and a purinergic P2Y1 receptor agonist, effectively increases calcium mobilization in HEK293 cells harboring the P2Y1 receptor with an EC50 of 9.4 nM for the human receptor. It also inhibits ADP-induced human isolated platelet aggregation with a Ki value of 4 μM and prompts relaxation in carbamoylcholine-tightened guinea pig taenia coli, achieving an EC50 of 426 nM.
• Storage: -20°C
• Note: For research use only
• Expiration Date: 12 months from date of receipt.