SOS1 agonist-1

• Catalog Number: orb2283443
• Category: Small Molecules
• Description: SOS1 agonist-1
• CAS Number: 2245237-61-8
• MW: 563.89
• SMILES: C(OC(C)(C)C)(=O)N1CC2(CN(C2)C=3N(CC4=CC(C)=C(F)C(C)=C4)C=5C(N3)=C(Br)C=C(Cl)C5)C1
• Formula: C₂₆H₂₉BrClFN₄O₂
• Biological Activity: SOS1 agonist-1 (compound 79) serves as an agonist for the Son of sevenless homologue 1 (SOS1), a crucial guanine nucleotide exchange factor involved in catalyzing the GDP to GTP exchange on RAS proteins, thus regulating RAS activation. By increasing nucleotide exchange on RAS, SOS1 agonists enhance cellular RAS-GTP levels and induce biphasic signaling alterations in ERK1/2 phosphorylation, playing a pivotal role in anti-cancer activity [1].
• Note: For research use only
• Expiration Date: 12 months from date of receipt.