SMU-C80

• Catalog Number: orb1910408
• Category: Small Molecules
• Description: SMU-C80 is a TLR2 agonist (EC50 = 31.02 ± 1.01 nM). SMU-C80, through TLR1/2, recruits the adaptor protein MyD88 and triggers the NF-κB pathway to release cytokines such as TNF-α and IL-1β from human, but not murine, cells. To the best of our knowledge, it is the first species-specific TLR1/2 agonist reported until now. Moreover, SMU-C80 increased the percentage of T, B, and NK cells ex vivo and activated the immune cells, which suppressed cancer cell growth in vitro.
• CAS Number: [2649309-05-5]
• MW: 428.5404
• SMILES: FC1=C2C(C=CC=C2)=C(NC(NC3=C(C(OC(C)C)=O)C(CCC4)=C4S3)=S)C=C1428.5404
• Formula: C₂₂H₂₁FN₂O₂S₂
• Note: For research use only
• Expiration Date: 12 months from date of receipt.