SKI-178

• Catalog Number: orb1298446
• Category: Small Molecules
• Description: SKI-178
• CAS Number: 1259484-97-3
• Purity: 99.20%
• MW: 394.42
• SMILES: COC1=CC=C(C=C1)C1=NNC(=C1)C(=O)N\N=C(/C)C1=CC=C(OC)C(OC)=C1
• Formula: C₂₁H₂₂N₄O₄
• Biological Activity: SKI-178 is a sphingosine kinase 1 (SphK1) inhibitor with IC50 of 0.1-1.8 μM. It induces prolonged mitosis followed by apoptotic cell death through the intrinsic apoptotic cascade. The sustained activation of CDK1 during prolonged mitosis, mediated by SKI-178 leads to the simultaneous phosphorylation of the prosurvival Bcl-2 family members, Bcl-2 and Bcl-xl, as well as the phosphorylation and subsequent degradation of Mcl-1.
• Storage: Store at -20°C for 12 months.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.