You have no items in your shopping cart.
You have no items in your shopping cart.
Catalog Number | orb2279586 |
---|---|
Category | Small Molecules |
Description | SK-575 is a Highly Potent and Efficacious Proteolysis-Targeting Chimera Degrader of PARP1 for Treating Cancers. SK-575 potently inhibits the growth of cancer cells bearing BRCA1/2 mutations and induces potent and specific degradation of PARP1 in various human cancer cells even at low picomolar concentrations. SK-575 achieves durable tumor growth inhibition in mice when used as a single agent or in combination with cytotoxic agents, such as temozolomide and cisplatin. |
CAS Number | [2523016-96-6] |
MW | 876.9709346 |
SMILES | O=C1N(C2CCC(=O)NC2=O)C(=O)C2=CC=CC(NCCNC(=O)CCCCCCCCCCC(N3CCN(C(C4C(=CC=C(CC5=NNC(=O)C6=CC=CC=C56)C=4)F)=O)CC3)=O)=C12 |
Formula | C47H53FN8O8 |
Note | For research use only |
Expiration Date | 12 months from date of receipt. |
2523017-04-9 | |
891 | |
C48H55FN8O8 |
Filter by Rating