SK-575-NEG

• Catalog Number: orb1982835
• Category: Small Molecules
• Description: SK-575-NEG
• CAS Number: 2523017-04-9
• MW: 891
• SMILES: CN1C(=O)CCC(N2C(=O)c3cccc(NCCNC(=O)CCCCCCCCCCC(=O)N4CCN(CC4)C(=O)c4cc(Cc5n[nH]c(=O)c6ccccc56)ccc4F)c3C2=O)C1=O
• Formula: C₄₈H₅₅FN₈O₈
• Biological Activity: SK-575-NEG (compound 28), a methylated derivative of SK-575, results from the methylation of the piperidine-2,6-dione's amino group in SK-575, serving as a control compound. It exhibits strong binding affinity to PARP1, evidenced by an IC50 of 2.64 nM. However, SK-575-NEG proved to be ineffective in promoting PARP1 degradation in MDA-MB-436 and Capan-1 cells, even at concentrations as high as 1 μM [1].
• Note: For research use only
• Expiration Date: 12 months from date of receipt.