SJB2-043

• Catalog Number: orb654609
• Category: Small Molecules
• Description: SJB2-043 is an inhibitor of the native USP1/UAF1 complex with IC50 of 544 nM.SJB2-043 causes a dose-dependent decrease in ubiquitin-specific protease 1 (USP1) levels and a concomitant degradation of inhibitor of DNA-binding-1 (ID1) protein in the K562 cells at a micromolar drug concentration. SJB2-043 also causes a decrease in the levels of other ID proteins, namely ID2 and ID3 in K562 cells. SJB2-043 causes a dose-dependent decrease in the number of viable K562 cells, with an EC50 of approximately 1.07 μM. Moreover, SJB2-043 induces apoptosis of K562 cells in a dose-dependent manner.
• CAS Number: [63388-44-3]
• MW: 275.2582643
• SMILES: C1C=CC(C2=NC3C(C4=CC=CC=C4C(=O)C=3O2)=O)=CC=1
• Formula: C₁₇H₉NO₃
• Note: For research use only
• Expiration Date: 12 months from date of receipt.