SJ46421

• Catalog Number: orb2695552
• Category: Small Molecules
• Description: SJ46421, a PROTAC protein degrader derived from (+)-JQ-1, targets KLHDC2. It efficiently forms a stable ternary complex with KLHDC2, exhibiting an IC50 of 7.8 nM. Furthermore, SJ46421 promotes the polyubiquitination of the BD2 domain of BRD2, BRD3, or BRD4.
• MW: 837.41
• SMILES: N#CC=1C=NN2C=C(C=C(C=3C=NC(=CC3)N4CC5N(CC6=CN=C(OC)C=C6)C(C4)C5)C12)N7CC(O)(C)C7
• Formula: C₄₂H₄₁ClN₈O₅S₂
• Storage: -20°C
• Note: For research use only
• Expiration Date: 12 months from date of receipt.