Sisunatovir HCl

• Catalog Number: orb757612
• Category: Small Molecules
• Description: Sisunatovir, also known as RV521, is a highly potent fusion inhibitor with efficacy against a panel of clinical isolates of RSV-A and RSV-B viruses. RV521 exhibited a mean IC50 of 1.2 nM against a panel of RSV A and B laboratory strains and clinical isolates with antiviral efficacy in the Balb/C mouse model of RSV infection. Oral bioavailability in preclinical species ranged from 42 to > 100% with evidence of highly efficient penetration into lung tissue. In healthy adult human volunteers experimentally infected with RSV, a potent antiviral effect was observed with a significant reduction in viral load and symptoms compared to placebo.
• CAS Number: [1903763-83-6]
• MW: 482.91
• SMILES: O=C(C12CC1)N(CC3=NC4=CC(CN)=CC=C4N3CCCC(F)(F)F)C5=C2C=CC(F)=C5.[H]Cl
• Formula: C₂₃H₂₃ClF₄N₄O
• Note: For research use only
• Expiration Date: 12 months from date of receipt.