SIAIS164018

• Catalog Number: orb1982824
• Category: Small Molecules
• Description: SIAIS164018, a PROTAC-based ALK and EGFR degrader derived from Brigatinib, exhibits IC50 values of 2.5 nM for ALK and 6.6 nM for ALK G1202R. It significantly hampers cancer cell migration and invasion, induces G1 cell cycle arrest, and triggers apoptosis, demonstrating superior properties compared to Brigatinib [1].
• CAS Number: 2353492-68-7
• Purity: 98.00%
• MW: 883.33
• SMILES: COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n1)N1CCC(CC1)N1CCN(CC1)C(=O)CNc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12
• Formula: C₄₃H₄₈ClN₁₀O₇P
• Biological Activity: SIAIS164018, a PROTAC-based ALK and EGFR degrader derived from Brigatinib, exhibits IC50 values of 2.5 nM for ALK and 6.6 nM for ALK G1202R. It significantly hampers cancer cell migration and invasion, induces G1 cell cycle arrest, and triggers apoptosis, demonstrating superior properties compared to Brigatinib [1].
• Storage: -20°C
• Note: For research use only
• Expiration Date: 12 months from date of receipt.