SIAIS164018 hydrochloride

• Catalog Number: orb2279007
• Category: Small Molecules
• Description: SIAIS164018 hydrochloride is a PROTAC-based degrader targeting ALK and EGFR, exhibiting IC50 values of 2.5 nM for ALK and 6.6 nM for ALK G1202R. It effectively suppresses cancer cell migration and invasion, induces G1 cell cycle arrest, and promotes apoptosis, demonstrating superior properties compared to Brigatinib [1].
• Purity: 98.00%
• MW: 919.79
• Formula: C₄₃H₄₉Cl₂N₁₀O₇P
• Biological Activity: SIAIS164018 hydrochloride is a PROTAC-based degrader targeting ALK and EGFR, exhibiting IC50 values of 2.5 nM for ALK and 6.6 nM for ALK G1202R. It effectively suppresses cancer cell migration and invasion, induces G1 cell cycle arrest, and promotes apoptosis, demonstrating superior properties compared to Brigatinib [1].
• Storage: -20°C
• Note: For research use only
• Expiration Date: 12 months from date of receipt.