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SI-CLP Antibody / CHID1 / Chitinase Domain Containing 1

Catalog Number: orb1826111

DispatchUsually dispatched within 5-10 working days
$ 780.00
Catalog Numberorb1826111
CategoryAntibodies
DescriptionSI-CLP (stabilin-1 interacting chitinase-like), also known as CHID1 (chitinase domain-containing protein 1), is a 393 amino acid secreted protein that belongs to the glycosyl hydrolase 18 family. SI-CLP interacts with STAB1 and localizes to lysosome in cells of monocytic, T, B and epithelial origin. SI-CLP is a saccharide- and LPS-binding protein with possible roles in pathogen sensing and endotoxin neutralization. Ligand-binding specificity relates to the length of the oligosaccharides, with preference for chitotetraose (in vitro). The SI-CLP protein is up-regulated by IL4/interleukin-4 and dexamethasone in the macrophages, and is also up-regulated by glucocorticoid. Existing as three alternatively spliced isoforms, the SI-CLP gene is conserved in chimpanzee, canine, bovine, mouse, rat, chicken, zebrafish, fruit fly, mosquito, A. thaliana and rice, and maps to human chromosome 11p15.5.
Species/HostMouse
ClonalityMonoclonal
Clone NumberCHID1/6368
Tested applicationsIHC-P
ReactivityHuman
IsotypeMouse IgG1, kappa
ImmunogenRecombinant full-length human SI-CLP protein was used as the immunogen for the CHID1 antibody.
Dilution rangeImmunohistochemistry (FFPE): 1-2ug/ml for 30 minutes at RT
ConjugationUnconjugated
Formula1 mg/ml in 1X PBS; BSA free, sodium azide free
Hazard InformationThis SI-CLP antibody is available for research use only.
UniProt IDQ9BWS9
StorageAliquot the SI-CLP antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
NoteFor research use only
Expiration Date12 months from date of receipt.
SI-CLP Antibody / CHID1 / Chitinase Domain Containing 1

IHC staining of FFPE human prostate tissue with SI-CLP antibody (clone CHID1/6368) HIER: boil tissue sections in pH9 10 mM Tris with 1 mM EDTA for 20 min and allow to cool before testing.

SI-CLP Antibody / CHID1 / Chitinase Domain Containing 1

IHC staining of FFPE human esophagus tissue with SI-CLP antibody (clone CHID1/6368) Inset: PBS used in place of primary Ab (secondary Ab negative control). HIER: boil tissue sections in pH9 10 mM Tris with 1 mM EDTA for 20 min and allow to cool before testing.