Se-Aspirin

SKU: orb2281205

Description

Se-Aspirin (Se-NSAID-8) has anticancer activity and gastroprotective effects, inhibits activation of proinflammatory and pro-survival NF-ĸB pathways, and inhibits the expression of anti-apoptotic targets downstream of NF-ĸB (e.g., Bcl-xL, Mcl-1, and survivin).Se-Aspirin induces Cell cycle arrest and activation of apoptosis accelerates ulcer healing and can be used to study pancreatic and colorectal cancer.

Research Area

Cell Biology

Key Properties

• CAS Number: 1850293-95-6
• MW: 311.2
• Purity: 98.07%
• Formula: C₁₂H₁₂N₂O₃Se
• SMILES: N#C[Se]CCNC(=O)C=1C=CC=CC1OC(=O)C
• Target: Apoptosis,Bcl-2 Family

Bioactivity

• In Vivo:
  Aspirin (5-150 mg/kg, PO, once) displays significant antipyretic activity in adult yeast-fever Male rats.
• In Vitro:
  Aspirin inhibits COX-1 and COX-2 in human articular chondrocytes with IC50 Values ​​of 3.57 μM and 29.3 μM, respectivel ; Aspirin acetylates serine 530 of COX-1, thereby blockin the synthesis of thromboxane A in platelets and reducing platelet aggregation; Aspirin inhibits COX-2 protein expression by interfering wit the binding of CCAAT/enhancer protein beta (C/EBPbeta) to its homologous sites o the COX-2 promoter/enhance ; Aspirin inhibits NF-κB-dependent transcription fro the lgκ enhancer and long terminal repeat (LTR) in human immunodeficiency virus (HIV)-transfected T cell ; Aspirin inhibits mitochondrial cytochrome c release, activation of p38 MAP kinase, and activation o the ceramide pathwa .

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

Se-NSAID-8, Se Aspirin, SeAspirin, Mcl-1, Apoptosis, Bcl-xL

Compound Identifiers

PubChem CID

91758292