SC144 hydrochloride

• Catalog Number: orb1909045
• Category: Small Molecules
• Description: SC144 hydrochloride, a first-in-class, orally active, small-molecule gp130 (IL6-beta) inhibitor, demonstrates potent inhibition of gp130 ligand-triggered signaling. By binding to gp130, it initiates gp130 phosphorylation (S782) and deglycosylation, impedes Stat3 phosphorylation and nuclear translocation, and suppresses the expression of downstream target genes. Furthermore, SC144 hydrochloride effectively induces apoptosis in human ovarian cancer cells [1].
• CAS Number: 917497-70-2
• Purity: 98.00%
• MW: 358.76
• SMILES: Cl.O=C(NNC1=NC=2C=C(F)C=CC2N3C=CC=C13)C4=NC=CN=C4
• Formula: C₁₆H₁₂ClFN₆O
• Biological Activity: SC144 hydrochloride, a first-in-class, orally active, small-molecule gp130 (IL6-beta) inhibitor, demonstrates potent inhibition of gp130 ligand-triggered signaling. By binding to gp130, it initiates gp130 phosphorylation (S782) and deglycosylation, impedes Stat3 phosphorylation and nuclear translocation, and suppresses the expression of downstream target genes. Furthermore, SC144 hydrochloride effectively induces apoptosis in human ovarian cancer cells [1].
• Storage: -20°C
• Note: For research use only
• Expiration Date: 12 months from date of receipt.