SC-10914

• Catalog Number: orb1737737
• Category: Small Molecules
• Description: SC-10914
• CAS Number: 76985-08-5
• Purity: 0.98
• MW: 241.29
• SMILES: C(C(C(O)=O)N)C1=CC=C(C=C1)C2=CC=CC=C2
• Formula: C₁₅H₁₅NO₂
• Biological Activity: SC10914 is a highly potent PARP inhibitor (PARP1 IC50 = 7.87 nM) with potent anti-proliferative activity against human BRCA deficient tumor cells (MDA-MB-436, BRCA1 deficient, IC50 = 4.03 nM, Capan-1 BRCA2 deficient, IC50 = 11.66 nM) and PTEN deficient tumor cells (HGC-27,PTEN deficient, IC50 = 0.35 μM). SC10914 showed potent anti-tumor activity in BRCA1/2 mutant tumor models and better pharmacokinetics profile has the potential to be selected as the clinical candidate for the treatment of treatment of BRCA1/2 deficient cancers.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.