SB297006

• Catalog Number: orb1302665
• Category: Small Molecules
• Description: SB297006
• CAS Number: 58816-69-6
• Purity: 99.65%
• MW: 342.35
• SMILES: [C@@H](CC1=CC=C(N(=O)=O)C=C1)(NC(=O)C2=CC=CC=C2)C(OCC)=O
• Formula: C₁₈H₁₈N₂O₅
• Biological Activity: SB297006 is an antagonist of C-C chemokine receptor 3 (CCR3; IC50 = 39 nM), which normally is activated by eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES, and MIP-1δ. It is at least 250-fold selective for CCR3 over a panel of other chemokine receptors. SB 297006 blocks CCR3-mediated calcium mobilization induced by eotaxin, eotaxin-2, and MCP-4 in transfected cells. It suppresses antigen-induced accumulation of Th2 lymphocytes and eosinophils in lungs of mice when delivered subcutaneously (100 mg/kg).
• Storage: Store at -20°C for 12 months.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.